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Socio-demographic and trauma-related predictors of depression within eight weeks of motor vehicle collision in the AURORA study
- Jutta Joormann, Samuel A. McLean, Francesca L. Beaudoin, Xinming An, Jennifer S. Stevens, Donglin Zeng, Thomas C. Neylan, Gari Clifford, Sarah D. Linnstaedt, Laura T. Germine, Scott L. Rauch, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Gregory Fermann, Lauren A. Hudak, Kamran Mohiuddin, Vishnu Murty, Meghan E. McGrath, John P. Haran, Jose Pascual, Mark Seamon, David A. Peak, Claire Pearson, Robert M. Domeier, Paulina Sergot, Roland Merchant, Leon D. Sanchez, Niels K. Rathlev, William F. Peacock, Steven E. Bruce, Deanna Barch, Diego A. Pizzagalli, Beatriz Luna, Steven E. Harte, Irving Hwang, Sue Lee, Nancy Sampson, Karestan C. Koenen, Kerry J. Ressler, Ronald C. Kessler
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- Journal:
- Psychological Medicine / Volume 52 / Issue 10 / July 2022
- Published online by Cambridge University Press:
- 29 October 2020, pp. 1934-1947
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Background
This is the first report on the association between trauma exposure and depression from the Advancing Understanding of RecOvery afteR traumA(AURORA) multisite longitudinal study of adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in the aftermath of a traumatic life experience.
MethodsWe focus on participants presenting at EDs after a motor vehicle collision (MVC), which characterizes most AURORA participants, and examine associations of participant socio-demographics and MVC characteristics with 8-week depression as mediated through peritraumatic symptoms and 2-week depression.
ResultsEight-week depression prevalence was relatively high (27.8%) and associated with several MVC characteristics (being passenger v. driver; injuries to other people). Peritraumatic distress was associated with 2-week but not 8-week depression. Most of these associations held when controlling for peritraumatic symptoms and, to a lesser degree, depressive symptoms at 2-weeks post-trauma.
ConclusionsThese observations, coupled with substantial variation in the relative strength of the mediating pathways across predictors, raises the possibility of diverse and potentially complex underlying biological and psychological processes that remain to be elucidated in more in-depth analyses of the rich and evolving AURORA database to find new targets for intervention and new tools for risk-based stratification following trauma exposure.
Perinatal anxiety and depressive symptoms and perception of child behavior and temperament in early motherhood
- Michelle L. Miller, Breanna M. Williams, Jennifer E. McCabe, J. Austin Williamson, Suzanne King, David P. Laplante, Kimberly J. Hart, Michael W. O’Hara
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- Journal:
- Journal of Developmental Origins of Health and Disease / Volume 12 / Issue 3 / June 2021
- Published online by Cambridge University Press:
- 10 September 2020, pp. 513-522
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The perinatal period is a vulnerable time for the development of psychopathology, particularly mood and anxiety disorders. In the study of maternal anxiety, important questions remain regarding the association between maternal anxiety symptoms and subsequent child outcomes. This study examined the association between depressive and anxiety symptoms, namely social anxiety, panic, and agoraphobia disorder symptoms during the perinatal period and maternal perception of child behavior, specifically different facets of development and temperament. Participants (N = 104) were recruited during pregnancy from a community sample. Participants completed clinician-administered and self-report measures of depressive and anxiety symptoms during the third trimester of pregnancy and at 16 months postpartum; child behavior and temperament outcomes were assessed at 16 months postpartum. Child development areas included gross and fine motor skills, language and problem-solving abilities, and personal/social skills. Child temperament domains included surgency, negative affectivity, and effortful control. Hierarchical multiple regression analyses demonstrated that elevated prenatal social anxiety symptoms significantly predicted more negative maternal report of child behavior across most measured domains. Elevated prenatal social anxiety and panic symptoms predicted more negative maternal report of child effortful control. Depressive and agoraphobia symptoms were not significant predictors of child outcomes. Elevated anxiety symptoms appear to have a distinct association with maternal report of child development and temperament. Considering the relative influence of anxiety symptoms, particularly social anxiety, on maternal report of child behavior and temperament can help to identify potential difficulties early on in mother–child interactions as well as inform interventions for women and their families.
TwinsUK: The UK Adult Twin Registry Update
- Serena Verdi, Golboo Abbasian, Ruth C. E. Bowyer, Genevieve Lachance, Darioush Yarand, Paraskevi Christofidou, Massimo Mangino, Cristina Menni, Jordana T. Bell, Mario Falchi, Kerrin S. Small, Frances M. K. Williams, Christopher J. Hammond, Deborah J. Hart, Timothy D. Spector, Claire J. Steves
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- Journal:
- Twin Research and Human Genetics / Volume 22 / Issue 6 / December 2019
- Published online by Cambridge University Press:
- 17 September 2019, pp. 523-529
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TwinsUK is the largest cohort of community-dwelling adult twins in the UK. The registry comprises over 14,000 volunteer twins (14,838 including mixed, single and triplets); it is predominantly female (82%) and middle-aged (mean age 59). In addition, over 1800 parents and siblings of twins are registered volunteers. During the last 27 years, TwinsUK has collected numerous questionnaire responses, physical/cognitive measures and biological measures on over 8500 subjects. Data were collected alongside four comprehensive phenotyping clinical visits to the Department of Twin Research and Genetic Epidemiology, King’s College London. Such collection methods have resulted in very detailed longitudinal clinical, biochemical, behavioral, dietary and socioeconomic cohort characterization; it provides a multidisciplinary platform for the study of complex disease during the adult life course, including the process of healthy aging. The major strength of TwinsUK is the availability of several ‘omic’ technologies for a range of sample types from participants, which includes genomewide scans of single-nucleotide variants, next-generation sequencing, metabolomic profiles, microbiomics, exome sequencing, epigenetic markers, gene expression arrays, RNA sequencing and telomere length measures. TwinsUK facilitates and actively encourages sharing the ‘TwinsUK’ resource with the scientific community — interested researchers may request data via the TwinsUK website (http://twinsuk.ac.uk/resources-for-researchers/access-our-data/) for their own use or future collaboration with the study team. In addition, further cohort data collection is planned via the Wellcome Open Research gateway (https://wellcomeopenresearch.org/gateways). The current article presents an up-to-date report on the application of technological advances, new study procedures in the cohort and future direction of TwinsUK.
Tolerance and the Basis for Selectivity to 2,4-D in Perennial Glycine Species
- Steve E. Hart, Scott Glenn, William W. Kenworthy
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- Journal:
- Weed Science / Volume 39 / Issue 4 / December 1991
- Published online by Cambridge University Press:
- 12 June 2017, pp. 535-539
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Twenty accessions within 11 perennial Glycine species plus soybean were tested for tolerance to 2,4-D. Soybean was severely injured by 2,4-D, but 13 of the Glycine accessions had 15% or less injury 4 weeks after 2,4-D application. Greatest 2,4-D tolerance occurred with accessions of G. latifolia and G. microphylla. There was no difference among tolerant accessions of G. latifolia and G. microphylla and susceptible accessions of G. canescens in recovery or absorption of 14C-2,4-D 1, 3, 7, or 14 days after treatment (DAT). Distribution of 14C from 14C-2,4-D in various plant parts was similar among accessions. Metabolism of 2,4-D in the tolerant accessions (81 to 89% 1 DAT) was higher and more rapid than in susceptible accessions (approximately 50%, 1 DAT). The same five metabolites plus parent 2,4-D were extracted from the treated leaf of all accessions at all sampling dates. However, relative distribution between metabolites differed between tolerant and susceptible accessions. More rapid metabolism of 2,4-D in treated leaves of tolerant Glycine accessions can explain differential 2,4-D responses.
Preemergence Weed Control in Conventional-Till Corn (Zea mays) with RPA 201772
- Bryan G. Young, Stephen E. Hart, F. William Simmons
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- Journal:
- Weed Technology / Volume 13 / Issue 3 / September 1999
- Published online by Cambridge University Press:
- 12 June 2017, pp. 471-477
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Field studies were conducted at Dekalb, Urbana, and Brownstown, IL, in 1996 and 1997 to evaluate corn (Zea mays) injury and weed control from preemergence applications of RPA 201772 alone and tank-mixed with metolachlor, atrazine, or both. No significant corn injury from RPA 201772 was observed at any time for all experiments. Giant foxtail (Setaria faberi) control at 60 days after treatment (DAT) was variable and ranged from 47 to 93% for RPA 201772 applied alone at 105 g ai/ ha. Giant foxtail control of at least 90% was observed by applying metolachlor at 1,120 g ai/ha with 105 g/ha RPA 201772. The addition of atrazine at either 1,120 or 1,680 g ai/ha improved control of giant foxtail compared with RPA 201772 applied alone at 105 g/ha in two of the six studies. RPA 201772 applied at 105 g/ha controlled at least 88% of velvetleaf (Abutilon theophrasti), Pennsylvania smartweed (Polygonum pensylvanicum), and smooth pigweed (Amaranthus hybridus). RPA 201772 controlled 88% or less of common waterhemp (Amaranthus rudis), common ragweed (Ambrosia artemisiifolia), and common cocklebur (Xanthium strumarium). Control of these three species was 92% or greater with RPA 201772 plus atrazine. Control of common lambsquarters (Chenopodium album) was at least 96% with RPA 201772 applied alone at any rate in four of the six studies. However, common lambsquarters control was 68 and 77% for RPA 201772 applied alone at 105 g/ha at Urbana and Brownstown in 1997, respectively, where high common lambsquarters densities were prevalent. Under these conditions, the addition of atrazine to RPA 201772 at 105 g/ha improved control of common lambsquarters. RPA 201772 has excellent potential to provide consistent control of velvetleaf compared with atrazine. In contrast, these studies indicate RPA 201772 may provide inconsistent control of certain weed species in different environments. In order to achieve consistent control of a broad spectrum of weed species, RPA 201772 must be combined with other herbicides.
Hybrid Kentucky Bluegrass Tolerance to Preemergence and Postemergence Herbicides
- Travis C. Teuton, Christopher L. Main, John C. Sorochan, J. Scott McElroy, William E. Hart, Carl E. Sams, Thomas C. Mueller
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- Journal:
- Weed Technology / Volume 22 / Issue 2 / June 2008
- Published online by Cambridge University Press:
- 20 January 2017, pp. 240-244
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Field studies were conducted near Knoxville, TN, from 2003 to 2005 to evaluate the response of ‘Thermal Blue’, a new interspecific hybrid Kentucky bluegrass to commonly applied PRE and POST herbicides for weed management. Dithiopyr, oryzalin, oxadiazon, pendimethalin, prodiamine, quinclorac, and trifluralin applied at seeding injured hybrid bluegrass greater than 81% and reduced hybrid bluegrass cover greater than 57%. In a second study, established hybrid bluegrass was treated POST with acetolactate synthase–inhibiting herbicides including bispyribac-sodium, chlorosulfuron, foramsulfuron, halosulfuron, imazapic, imazaquin, metsulfuron, rimsulfuron, sulfosulfuron, and trifloxysulfuron at low and high rates (one and two times the suggested use rates in Kentucky bluegrass or other turfgrasses). By 5 wk after treatment (WAT), foramsulfuron at 88 g ai/ha and trifloxysulfuron at 35 g ai/ha injured hybrid bluegrass greater than 26% and reduced visually estimated quality and chlorophyll meter indices. However, hybrid bluegrass injury was no longer evident at 10 WAT. In a third study, established hybrid bluegrass was treated with clethodim, diclofop-methyl, fluazifop-p-butyl, and sethoxydim applied at low, medium, and high rates (0.5, 1, and 2 times the registered Kentucky bluegrass or other turfgrass use rates). Clethodim applied at 280 and 560 g ai/ha, fluazifop at 420 g ai/ha, and sethoxydim at 630 g ai/ha injured hybrid bluegrass 5 WAT. These treatments also reduced quality (to less than 5 on a scale of 1 to 9) and chlorophyll meter indices (24 to 37%) when compared to the untreated control. By 10 WAT, only clethodim at 560 g ai/ha caused injury (14%). By 10 WAT, hybrid bluegrass had recovered and injury was only observed in plots treated with clethodim at 560 g ai/ha. No differences in chlorophyll indices or quality were observed at 10 WAT for any POST graminicides.
Increased Glyphosate Tolerance in ‘Aurora Gold’ Hard Fescue (Festuca longifolia)
- Stephen E. Hart, Jeffrey F. Derr, Darren W. Lycan, Crystal Rose-Fricker, William A. Meyer
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- Weed Technology / Volume 19 / Issue 3 / September 2005
- Published online by Cambridge University Press:
- 20 January 2017, pp. 640-646
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Studies were conducted in New Jersey and Virginia to evaluate the response of ‘Aurora Gold’ hard fescue, which had undergone five cycles of phenotypic recurrent selection for increased glyphosate tolerance, to direct applications of glyphosate. ‘Discovery’ hard fescue, which had not undergone recurrent selection, was also included in the study. Glyphosate treatments were initiated in early/mid-May and applied once, twice, or three times at 4- to 5-wk intervals at rates ranging from 0.1 to 1.6 kg ae/ha. Aurora Gold was more tolerant to glyphosate than Discovery in all experiments, indicating that recurrent selection was successful in increasing glyphosate tolerance in hard fescue. Single applications of glyphosate at rates ranging from 0.6 to 0.8 kg/ha could be applied to Aurora Gold with minimal injury or stand thinning (<20%), whereas multiple applications of glyphosate could be applied at rates ranging from 0.4 to 0.6 kg/ha. The use of Aurora Gold in areas planted to hard fescue, such as golf course roughs, vineyards, orchards, and landscapes, would allow the integration of direct glyphosate applications into an overall weed management program providing potential economic and environmental benefits.
Site-Specific Weed Management in Corn (Zea mays)
- Joyce Tredaway-Ducar, Gaylon D. Morgan, John B. Wilkerson, William E. Hart, Robert M. Hayes, Thomas C. Mueller
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- Journal:
- Weed Technology / Volume 17 / Issue 4 / December 2003
- Published online by Cambridge University Press:
- 20 January 2017, pp. 711-717
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Site-specific weed management can increase crop production efficiency by minimizing herbicide input costs without compromising crop yields. A reduction in herbicide inputs resulting from site-specific weed management may also decrease the probability level of nonpoint pollution compared with conventional herbicide applications. A 4.5-ha field was selected to compare site-specific and conventional weed management techniques in 1997 and 1998 at Knoxville, TN. Variable rate applications (VRAs) of atrazine preemergence (PRE) followed by dicamba postemergence (POST) were investigated for the reduction of herbicide inputs and their resulting impact on weed control and corn yield. VRAs of atrazine were on the basis of weed density data collected in 1996. VRAs of dicamba were according to common cocklebur density evaluations within the field. Compared with conventional applications, atrazine usage was decreased by 43 and 32% in the site-specific application treatments in 1997 and 1998, respectively. VRAs of dicamba reduced herbicide inputs by greater than 45% for 1997 and 1998. Corn yields were similar for the conventional and site-specific treatments in both years. On the basis of these data, site-specific herbicide applications have the greatest potential and least risk for managing weeds when POST or PRE + POST variable rate herbicide applications are used.
Effect of Venturi-Type Nozzles and Application Volume on Postemergence Herbicide Efficacy
- Robert E. Etheridge, William E. Hart, Robert M. Hayes, Thomas C. Mueller
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- Journal:
- Weed Technology / Volume 15 / Issue 1 / March 2001
- Published online by Cambridge University Press:
- 20 January 2017, pp. 75-80
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Field studies were conducted to compare venturi-type nozzles to a fan nozzle with respect to the efficacy of postemergence herbicides applied to common cocklebur and broadleaf signalgrass. Spray solutions of glufosinate, glyphosate, and paraquat were applied through all combinations of three nozzles and two application volumes. Venturi nozzles were a Delavan Raindrop Ultra (RU) and a Spraying Systems AI Teejet (AI). A Spraying Systems XR Teejet (XR) fan nozzle was included as a standard. Previous work indicated droplet size spectra differed among these nozzles. There was a difference in common cocklebur control among nozzles (AI = XR > RU), although control was at least 90% for all nozzles. Herbicide choice had a greater effect on broadleaf signalgrass control than nozzle type. Broadleaf signalgrass control differed among herbicides (glufosinate = paraquat > glyphosate) and among nozzles (AI = XR > RU). Herbicide performance varied between nozzles (AI > RU), but the AI nozzle was as effective as the XR fan nozzle.
Comparison of Weed Management Systems in Narrow-Row, Glyphosate- and Glufosinate-Resistant Soybean (Glycine max)
- Michelle L. Wiesbrook, William G. Johnson, Stephen E. Hart, Pauley R. Bradley, Loyd M. Wax
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- Journal:
- Weed Technology / Volume 15 / Issue 1 / March 2001
- Published online by Cambridge University Press:
- 20 January 2017, pp. 122-128
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Field experiments were conducted near DeKalb and Urbana, IL, and Columbia, MO, in 1997 and 1998 to evaluate weed management systems in glyphosate- and glufosinate-resistant soybean planted in 18-cm rows. Overall weed control was improved to a greater extent when the rate of glufosinate was increased from 300 to 400 g ai/ha than when the rate of glyphosate increased from 630 to 840 g ae/ha. Sequential applications of glufosinate improved control over single applications, whereas sequential treatments of glyphosate generally provided no advantages over single applications. When averaged across all weed species in these trials, the systems that provided 95% or higher average control were sequential applications of glufosinate, sequential applications of glyphosate, and clomazone followed by (fb) glyphosate. Single applications of glufosinate provided somewhat variable control of giant foxtail, common lambsquarters, ragweed, and common cocklebur similar to that observed with pendimethalin fb imazethapyr. The addition of fomesafen to glufosinate did not improve control of any of the weeds in this study with the exception of velvetleaf at DeKalb. The addition of clomazone to glufosinate treatments resulted in slightly better giant foxtail and velvetleaf control. Single applications of glyphosate provided somewhat variable control of giant ragweed at DeKalb in 1997 and ivyleaf morningglory and common cocklebur control at Columbia. The addition of fomesafen to glyphosate provided an increase in ivyleaf morningglory and common cocklebur control at Columbia but did not improve control of any other species. The addition of clomazone to glyphosate-based programs resulted in slightly higher velvetleaf, common cocklebur, and ivyleaf morningglory control. In the glyphosate-based herbicide programs there were no substantial differences in relative yield, with all programs protecting over 95% of soybean yield. Glufosinate-based programs were effective in protecting 85 to 92% of soybean yield.
Economics of Weed Management in Glufosinate-Resistant Corn (Zea mays L.)1
- Pauley R. Bradley, William G. Johnson, Stephen E. Hart, Michelle L. Buesinger, Raymond E. Massey
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- Journal:
- Weed Technology / Volume 14 / Issue 3 / September 2000
- Published online by Cambridge University Press:
- 20 January 2017, pp. 495-501
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Field experiments were conducted in 1997 and 1998 near Columbia and Novelty, MO, and at Urbana, IL, to evaluate corn injury, weed control, corn yield, and estimated economic returns with weed management programs in glufosinate-resistant corn. Herbicide programs included acetochlor preemergence (PRE) followed by glufosinate alone or with atrazine postemergence (POST) and total POST programs consisting of single and sequential applications of glufosinate alone or tank mixed with acetochlor, atrazine, or acetochlor plus atrazine. Metolachlor PRE followed by dicamba plus atrazine early POST (EPOST) and metolachlor plus atrazine PRE were included for comparison. In the total POST treatments, mid-POST applications controlled shattercane and common cocklebur better than EPOST applications. However, yield reductions as high as 23% occurred because of early-season weed interference, although weeds were controlled later in the season. Applying atrazine with glufosinate generally increased control of giant foxtail, common cocklebur, morningglory species, and common waterhemp compared to glufosinate alone, but did not increase control of common lambsquarters, velvetleaf, or Pennsylvania smartweed. Corn yield was positively correlated with weed control (r = 0.88) and more strongly dependent on grass (r = 0.82) than broadleaf (r = 0.70) weed control. Net incomes were positively correlated to corn yield (r = 0.73). Four of the top six net income-producing treatments included two herbicide applications. Three of the treatments were PRE followed by POST programs, and the fourth was a sequential POST treatment of glufosinate.
Efficacy and Economics of Weed Management in Glyphosate-Resistant Corn (Zea mays)1
- William G. Johnson, Pauley R. Bradley, Stephen E. Hart, Michelle L. Buesinger, Raymond E. Massey
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- Journal:
- Weed Technology / Volume 14 / Issue 1 / March 2000
- Published online by Cambridge University Press:
- 20 January 2017, pp. 57-65
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Field experiments were conducted in 1997 and 1998 near Columbia and Novelty, MO, and Urbana, IL, to evaluate crop injury, weed control, corn yield, and net economic returns provided by weed control programs in glyphosate-resistant corn. The herbicide programs evaluated included acetochlor preemergence (PRE) followed by (fb) glyphosate with or without atrazine postemergence (POST) and total POST programs consisting of single and sequential applications of glyphosate alone and tank-mixed with actochlor, atrazine, or both. Metolachlor PRE fb dicamba plus atrazine POST and metolachlor plus atrazine PRE were included for comparison. In the total POST treatments, mid-post (MPOST) applications provided better control than early-post (EPOST) applications on weeds that germinated throughout the growing season such as shattercane and common cocklebur, but also resulted in yield reductions of up to 23% caused by early-season weed competition. The addition of atrazine to glyphosate POST generally increased control of common cocklebur, morningglory species, and common waterhemp. EPOST or PRE fb EPOST applications generally provided higher yields than MPOST treatments, although MPOST treatments often provided equal or greater weed control at midseason. Treatments including two herbicide applications tended to provide greater weed control, yield, and profit than those with a single application. Input costs for glyphosate-resistant corn are slightly higher than nontransgenic hybrids. However, net economic returns are similar and the use of glyphosate POST allows greater flexibility in POST weed management decisions.
The Role of Soil and Landscape Factors in Chinese Privet (Ligustrum sinense) Invasion in the Appalachian Piedmont
- Donald L. Hagan, Elena A. Mikhailova, Timothy M. Shearman, Patrick T. Ma, Jedidah S. Nankaya, Samantha K. Hart, Hillary E. Valdetero, William C. Bridges, He Yun
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- Journal:
- Invasive Plant Science and Management / Volume 7 / Issue 3 / September 2014
- Published online by Cambridge University Press:
- 20 January 2017, pp. 483-490
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There is a limited understanding about the ecological mechanisms that enable certain plant species to become successful invaders of natural areas. This study was conducted to determine the soil and landscape characteristics that correlate with invasion of Chinese privet (CHP), and to develop a model to predict the probability of CHP invasion in Piedmont forests. A landscape ecosystem classification (LEC) system—based on the percentage of clay in the B horizon, depth to maximum clay (cm), exposure, terrain shape, and aspect (degrees)—was used to determine the soil moisture characteristics of invaded and uninvaded plots. Additional measurements included the cover classes of CHP and other species, litter depth (cm), slope (degrees), overstory basal area (m2 ha−1), and soil chemical properties. CHP invasion was negatively correlated with overstory basal area and slope and positively with litter depth and pH. A stepwise logistic regression model containing these four variables was highly sensitive, with an overall accuracy of 78%. Given the accuracy of this model, we propose that it can be used to calculate the probability of invasion in a given area, provided that some basic, readily obtainable site characteristics are known.
Contributors
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. Hull, Patricia Huntington, Thomas Hurka, Paul Hurley, Rosalind Hursthouse, Guillermo Hurtado, Ronald E. Hustwit, Sarah Hutton, Jonathan Jenkins Ichikawa, Harry A. Ide, David Ingram, Philip J. Ivanhoe, Alfred L. Ivry, Frank Jackson, Dale Jacquette, Joseph Jedwab, Richard Jeffrey, David Alan Johnson, Edward Johnson, Mark D. Jordan, Richard Joyce, Hwa Yol Jung, Robert Hillary Kane, Tomis Kapitan, Jacquelyn Ann K. Kegley, James A. Keller, Ralph Kennedy, Sergei Khoruzhii, Jaegwon Kim, Yersu Kim, Nathan L. King, Patricia Kitcher, Peter D. Klein, E. D. Klemke, Virginia Klenk, George L. Kline, Christian Klotz, Simo Knuuttila, Joseph J. Kockelmans, Konstantin Kolenda, Sebastian Tomasz Kołodziejczyk, Isaac Kramnick, Richard Kraut, Fred Kroon, Manfred Kuehn, Steven T. Kuhn, Henry E. Kyburg, John Lachs, Jennifer Lackey, Stephen E. Lahey, Andrea Lavazza, Thomas H. Leahey, Joo Heung Lee, Keith Lehrer, Dorothy Leland, Noah M. Lemos, Ernest LePore, Sarah-Jane Leslie, Isaac Levi, Andrew Levine, Alan E. Lewis, Daniel E. Little, Shu-hsien Liu, Shu-hsien Liu, Alan K. L. Chan, Brian Loar, Lawrence B. Lombard, John Longeway, Dominic McIver Lopes, Michael J. Loux, E. J. Lowe, Steven Luper, Eugene C. Luschei, William G. Lycan, David Lyons, David Macarthur, Danielle Macbeth, Scott MacDonald, Jacob L. Mackey, Louis H. Mackey, Penelope Mackie, Edward H. Madden, Penelope Maddy, G. B. Madison, Bernd Magnus, Pekka Mäkelä, Rudolf A. Makkreel, David Manley, William E. Mann (W.E.M.), Vladimir Marchenkov, Peter Markie, Jean-Pierre Marquis, Ausonio Marras, Mike W. Martin, A. P. Martinich, William L. McBride, David McCabe, Storrs McCall, Hugh J. McCann, Robert N. McCauley, John J. McDermott, Sarah McGrath, Ralph McInerny, Daniel J. McKaughan, Thomas McKay, Michael McKinsey, Brian P. McLaughlin, Ernan McMullin, Anthonie Meijers, Jack W. Meiland, William Jason Melanson, Alfred R. Mele, Joseph R. Mendola, Christopher Menzel, Michael J. Meyer, Christian B. Miller, David W. Miller, Peter Millican, Robert N. Minor, Phillip Mitsis, James A. Montmarquet, Michael S. Moore, Tim Moore, Benjamin Morison, Donald R. Morrison, Stephen J. Morse, Paul K. Moser, Alexander P. D. Mourelatos, Ian Mueller, James Bernard Murphy, Mark C. Murphy, Steven Nadler, Jan Narveson, Alan Nelson, Jerome Neu, Samuel Newlands, Kai Nielsen, Ilkka Niiniluoto, Carlos G. Noreña, Calvin G. Normore, David Fate Norton, Nikolaj Nottelmann, Donald Nute, David S. Oderberg, Steve Odin, Michael O’Rourke, Willard G. Oxtoby, Heinz Paetzold, George S. Pappas, Anthony J. Parel, Lydia Patton, R. P. Peerenboom, Francis Jeffry Pelletier, Adriaan T. Peperzak, Derk Pereboom, Jaroslav Peregrin, Glen Pettigrove, Philip Pettit, Edmund L. Pincoffs, Andrew Pinsent, Robert B. Pippin, Alvin Plantinga, Louis P. Pojman, Richard H. Popkin, John F. Post, Carl J. Posy, William J. Prior, Richard Purtill, Michael Quante, Philip L. Quinn, Philip L. Quinn, Elizabeth S. Radcliffe, Diana Raffman, Gerard Raulet, Stephen L. Read, Andrews Reath, Andrew Reisner, Nicholas Rescher, Henry S. Richardson, Robert C. Richardson, Thomas Ricketts, Wayne D. Riggs, Mark Roberts, Robert C. Roberts, Luke Robinson, Alexander Rosenberg, Gary Rosenkranz, Bernice Glatzer Rosenthal, Adina L. Roskies, William L. Rowe, T. M. Rudavsky, Michael Ruse, Bruce Russell, Lilly-Marlene Russow, Dan Ryder, R. M. Sainsbury, Joseph Salerno, Nathan Salmon, Wesley C. Salmon, Constantine Sandis, David H. Sanford, Marco Santambrogio, David Sapire, Ruth A. Saunders, Geoffrey Sayre-McCord, Charles Sayward, James P. Scanlan, Richard Schacht, Tamar Schapiro, Frederick F. Schmitt, Jerome B. Schneewind, Calvin O. Schrag, Alan D. Schrift, George F. Schumm, Jean-Loup Seban, David N. Sedley, Kenneth Seeskin, Krister Segerberg, Charlene Haddock Seigfried, Dennis M. Senchuk, James F. Sennett, William Lad Sessions, Stewart Shapiro, Tommie Shelby, Donald W. Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
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- The Cambridge Dictionary of Philosophy
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- 05 August 2015
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- 27 April 2015, pp ix-xxx
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A study of National Health Service management of chronic osteoarthritis and low back pain
- Oliver R. Hart, Ruth M. Uden, James E. McMullan, Mark S. Ritchie, Timothy D. Williams, Blair H. Smith
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- Primary Health Care Research & Development / Volume 16 / Issue 2 / March 2015
- Published online by Cambridge University Press:
- 27 March 2014, pp. 157-166
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Aim
To describe treatment and referral patterns and National Health Service resource use in patients with chronic pain associated with low back pain or osteoarthritis, from a Primary Care perspective.
BackgroundOsteoarthritis and low back pain are the two commonest debilitating causes of chronic pain, with high health and social costs, and particularly important in primary care. Understanding current practice and resource use in their management will inform health service and educational requirements and the design and optimisation of future care.
MethodMulti-centre, retrospective, descriptive study of adults (⩾18 years) with chronic pain arising from low back pain or osteoarthritis, identified through primary care records. Five general practices in Scotland, England (two), Northern Ireland and Wales. All patients with a diagnosis of low back pain or osteoarthritis made on or before 01/09/2006 who had received three or more prescriptions for pain medication were identified and a sub-sample randomly selected then consented to an in-depth review of their medical records (n=264). Data on management of chronic pain were collected retrospectively from patients’ records for three years from diagnosis (‘newly diagnosed’ patients) or for the most recent three years (‘established’ patients).
FindingsPatients received a wide variety of pain medications with no overall common prescribing pattern. GP visits represented the majority of the resource use and ‘newly diagnosed’ patients were significantly more likely to visit their GP for pain management than ‘established’ patients. Although ‘newly diagnosed’ patients had more referrals outside the GP practice, the number of visits to secondary care for pain management was similar for both groups.
ConclusionThis retrospective study confirmed the complexity of managing these causes of chronic pain and the associated high resource use. It provides an in-depth picture of prescribing and referral patterns and of resource use.
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- By James Ahn, Eric L. Anderson, Annette L. Beautrais, Dennis Beedle, Jon S. Berlin, Benjamin L. Bregman, Peter Brown, Suzie Bruch, Jonathan Busko, Stuart Buttlaire, Laurie Byrne, Gerald Carroll, Valerie A. Carroll, Margaret Cashman, Joseph R. Check, Lara G. Chepenik, Robert N. Cuyler, Preeti Dalawari, Suzanne Dooley-Hash, William R. Dubin, Mila L. Felder, Avrim B. Fishkind, Reginald I. Gaylord, Rachel Lipson Glick, Travis Grace, Clare Gray, Anita Hart, Ross A. Heller, Amanda E. Horn, David S. Howes, David C. Hsu, Andy Jagoda, Margaret Judd, John Kahler, Daryl Knox, Gregory Luke Larkin, Patricia Lee, Jerrold B. Leikin, Eddie Markul, Marc L. Martel, J. D. McCourt, MaryLynn McGuire Clarke, Mark Newman, Anthony T. Ng, Barbara Nightengale, Kimberly Nordstrom, Jagoda Pasic, Jennifer Peltzer-Jones, Marcia A. Perry, Larry Phillips, Paul Porter, Seth Powsner, Michael S. Pulia, Erin Rapp, Divy Ravindranath, Janet S. Richmond, Silvana Riggio, Harvey L. Ruben, Derek J. Robinson, Douglas A. Rund, Omeed Saghafi, Alicia N. Sanders, Jeffrey Sankoff, Lorin M. Scher, Louis Scrattish, Richard D. Shih, Maureen Slade, Susan Stefan, Victor G. Stiebel, Deborah Taber, Vaishal Tolia, Gary M. Vilke, Alvin Wang, Michael A. Ward, Joseph Weber, Michael P. Wilson, James L. Young, Scott L. Zeller
- Edited by Leslie S. Zun
- Edited in association with Lara G. Chepenik, Mary Nan S. Mallory
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- Behavioral Emergencies for the Emergency Physician
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- 05 April 2013
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- 21 March 2013, pp viii-xii
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- By Nozomi Akanuma, Gonzalo Alarcón, R. Arunachalam, Sarah H. Bernard, Frank M. C. Besag, Istvan Bodi, Stephen Brown, Franz Brunnhuber, Antonella Cerquiglini, J. Helen Cross, R. Shane Delamont, Archana Desurkar, Lee Drummond, Rona Eade, Robert D. C. Elwes, Bidi Evans, Peter Fenwick, Colin D. Ferrie, Paul L. Furlong, Laura H. Goldstein, Sally Gomersall, Sushma Goyal, Jane Hanna, Yvonne Hart, Dominic C. Heaney, Graham E. Holder, Mrinalini Honavar, Elaine Hughes, Jozef M. Jarosz, John G. R. Jefferys, Jane Juler, Mathias Koepp, Michalis Koutroumanidis, Maureen Lahiff, Louis Lemieux, David McCormick, Brian Meldrum, John D. C. Mellers, Nicholas Moran, John Moriarty, Robin G. Morris, Nandini Mullatti, Lina Nashef, Jennifer Nightingale, T. J. von Oertzen, Corina O'Neill, Philip N. Patsalos, Stella Pearson, Charles E. Polkey, Ronit Pressler, Edward H. Reynolds, Mark P. Richardson, Leone Ridsdale, Robert Robinson, Greg Rogers, Euan M. Ross, Richard P. Selway, Stefano Seri, Simeran Sharma, Graeme J. Sills, Andrew Simmons, Shiri Spector, Mark Stevenson, Jade N. Thai, Brian Toone, Antonio Valentín, Nuria T. Villagra, Matthew Walker, William Whitehouse
- Edited by Gonzalo Alarcón, King's College London, Antonio Valentín, King's College London
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- Introduction to Epilepsy
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- 05 July 2012
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- 26 April 2012, pp xii-xv
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- By Mohamed Aboulghar, Ahmed Abou-Setta, Mary E. Abusief, G. David Adamson, R. J. Aitken, Hesham Al-Inany, Baris Ata, Hamdy Azab, Adam Balen, David H. Barad, Pedro N. Barri, C. Blockeel, Giuseppe Botta, Mark Bowman, Chris Brewer, Dominique M. Butawan, Sandra A. Carson, Hai Ying Chen, Anne Clark, Buenaventura Coroleu, S. Das, C. Dechanet, H. Déchaud, Cora de Klerk, Sheryl de Lacey, S. Deutsch-Bringer, P. Devroey, Didier Dewailly, Hakan E. Duran, Walid El Sherbiny, Tarek El-Toukhy, Johannes L. H. Evers, Cynthia Farquhar, Rodney D. Franklin, Juan A. Garcia-Velasco, David K. Gardner, Norbert Gleicher, Gedis Grudzinskas, Roger Hart, B Hédon, Colin M. Howles, Jack Yu Jen Huang, N. P. Johnson, Hey-Joo Kang, Gab Kovacs, Ben Kroon, Anver Kuliev, William H. Kutteh, Nick Macklon, Ragaa Mansour, Lamiya Mohiyiddeen, Lisa J. Moran, David Mortimer, Sharon T. Mortimer, Luciano G. Nardo, Robert J. Norman, Willem Ombelet, Luk Rombauts, Zev Rosenwaks, Francisco J. Ruiz Flores, Anthony J. Rutherford, Gavin Sacks, Denny Sakkas, M. W. Seif, Ayse Seyhan, Caroline Smith, Kate Stern, Elizabeth A. Sullivan, Sesh Kamal Sunkara, Seang Lin Tan, Mohamed Taranissi, Kelton P. Tremellen, Wendy S. Vitek, V. Vloeberghs, Bradley J. Van Voorhis, S. F. van Voorst, Amr Wahba, Yueping A. Wang, Klaus E. Wiemer
- Edited by Gab Kovacs, Monash University, Victoria
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- How to Improve your ART Success Rates
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- 05 July 2011
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- 30 June 2011, pp viii-xii
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